Steroidal VS Non-Steroidal SARMsIn the early 1990s, scientists created a non-steroidal version of these SARMs by making them protein-based. The difference between these two types of SARMs is most easily described as a lock and key system, The cells in the body act as locks and the binding sites of the cells are are the keyholes. Steroidal SARMs have the ability to act like a master key unlocking every cell to promote protein synthesis and growth, even in cells you don’t want to “unlock”. Nonsteroidal SARMs are designed specifically for one type of lock, therefore, it will only affect areas of the DNA that prevent muscle and bone wastage while also promoting growth in these areas. Nonsteroidal SARMs have been used for bodybuilding, powerlifting and a multitude of other sports since the start of its popularity. Their benefit to side effect ratio has been tested since the 1990s with no evidence suggesting harm. This breakthrough in scientific technology continues to suggest SARMs are the future of anabolics and will eventually replace steroid therapy. This is not to say that nonsteroidal SARMs are the answers to all our problems. Although a protein-based SARMs have very limited side effects with large benefits for strength and muscle gains, SARMs require a much longer period of use and cannot yet compare to the effectiveness of a steroid.
SARMS vs. ProhormonesProhormones were the first ones introduced to the market. However, these supplements don’t have the muscle growth effects of authentic steroids and cause major side effects that make them unsafe for human use. SARMS are more of an upgrade to anabolic steroids. It can be administered orally, minimizing the effects of testosterone blood levels. SARMS are also believed to cure various diseases in which steroids and other medicines treated earlier. It also shows promise to replace androgens which can yield similar desirable results on muscle tissue as steroids. Studies have shown the ability of SARMs to increase muscle and bone mass dramatically in animals while having no adverse impact on the prostate.
How Do SARMS Work?As we age, our endurance, power and skeletal muscle mass deteriorate due to the loss of type 2 muscle fibers. This hinders individuals to function normally. With SARMS, skeletal muscle mass and strength in androgen-deficient people can be enhanced. There are 2 types of administering SARMS – orally or in injectable dosages. The anabolic effect is expected to be the same as testosterone. Moreover, it’s also said to produce dose-dependent improvements in bone mineral density and motorized strength apart from the ability to decrease body fat and increase lean body mass. SARMS link to the same receptors that old steroids such as Dianabol and testosterone would connect to, but minus the drawbacks and side effects of traditional steroids and prohormones. This is a fresh start in the advancement of muscle pharmacology as SARMS can help enhance muscle mass while helping you reduce body fat and boost athletic performance beyond your imagination.
The Most Popular SARMSThere are many SARMS, but here are the 4 main SARMS that are currently offered and most applicable to athletes, bodybuilders and fitness enthusiasts:
- LGD-4033 – a potent, non-steroidal bodybuilding supplement for enhancing lean muscle mass and reducing body fat
- Ostarine (MK-2866) – selective for anabolic activity at certain ARs, great for maintaining and increasing lean body mass and recomping
- S4 (Andarine) – selective for bone tissue (mostly low virilization), aimed to cure osteoporosis and won’t produce the development of prostate and other secondary sexual organs
- RAD140 – this is probably one of the most exciting SARMs, as well as the most current. In fact, aside from the muscle building effects seems to look like a possible cure for Alzheimer’s.
Benefits of SARMSSARMS are believed to have the capacity to employ the benefits of anabolic supplements while reducing the side effects of steroids.
- Non-toxic (won’t cause liver damage)
- Avoids bone loss (direct action of testosterone in bone thru the AR-mediated conduit is critical for its anabolic effects in the bone)
- Decreases the threat of prostate problems in men without muscle mass loss
- Won’t impede your HPTA
- Similar effects with testosterone
- No estrogen and Dihydrotestosterone (a hydrogen hormone) conversion
- Muscle loss prevention (during the cutting period)
- Lean muscle development
- Improved strength
- Faster injury recovery
- Joint healing abilities
- PCT use following anabolics
Side Effects of SARMSSARMs have very little side effects, making them very popular and promising for that reason. In the Oxford Journal of Gerontology Series A: Biological Sciences and Medical Sciences, the popular nonsteroidal SARM LGD 4033 (Ligandrol) has been recently studied for its effectiveness and safety in healthy young men. Results were favorable, indicated by hormone and lipid levels returning to normal without the use of a post cycle therapy. No dangers were detected throughout the study. Although there was noticeable suppression in testosterone and HDL cholesterol, it was not significant enough to cause adverse reactions. Because LGD 4033 is considered one of the strongest and most potent nonsteroidal SARMs available, it is not likely that less potent SARMs will produce any harmful effects (Bhasin, 2010). Be responsible, and in 99.9% of cases, users will not have any side effects from the use of SARMs. Current research has so far agreed with that conclusion.
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Concluding ThoughtsWith SARMS showing great promise for selective high anabolic muscle activity and in preventing muscle wasting and age-related illnesses without the negative side effects associated with anabolic steroids and prohormones, SARMS could be the next big thing. The IOC (International Olympic Committee) is even preparing for the use of SARMS with Olympic athletes. It’s Anabolics 3.0 and the “Universal Soldier Formula” of the future! Additional questions? You can also check out our article entitled SARMs: Questions & Answers What are your thoughts on SARMS? Feel free to leave a comment below.
Miller, Chris P., Maysoun Shomali, C. Richard Lyttle, Louis St. L. O’Dea, Hillary Herendeen, Kyla Gallacher, Dottie Paquin, Dennis R. Compton, Bishwabhusan Sahoo, Sean A. Kerrigan, Matthew S. Burge, Michael Nickels, Jennifer L. Green, John A. Katzenellenbogen, Alexei Tchesnokov, and Gary Hattersley. “Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140.” ACS Medicinal Chemistry Letters. American Chemical Society, 10 Feb. 2011. Web. 22 Apr. 2017. Dubois, Vanessa, Ioannis Simitsidellis, Michaël R. Laurent, Ferran Jardi, Philippa T. K. Saunders, Dirk Vanderschueren, and Frank Claessens. “Enobosarm (GTx-024) Modulates Adult Skeletal Muscle Mass Independently of the Androgen Receptor in the Satellite Cell Lineage.” Endocrinology. Oxford University Press, 01 Dec. 2015. Web. 22 Apr. 2017. Dubois, V., I. Simitsidellis, M. R. Laurent, F. Jardi, P. T. Saunders, D. Vanderschueren, and F. Claessens. “Enobosarm (GTx-024) Modulates Adult Skeletal Muscle Mass Independently of the Androgen Receptor in the Satellite Cell Lineage.” Endocrinology. U.S. National Library of Medicine, Dec. 2015. Web. 22 Apr. 2017. Basaria, Shehzad, Lauren Collins, E. Lichar Dillon, Katie Orwoll, Thomas W. Storer, Renee Miciek, Jagadish Ulloor, Anqi Zhang, Richard Eder, Heather Zientek, Gilad Gordon, Syed Kazmi, Melinda Sheffield-Moore, and Shalender Bhasin. “The Safety, Pharmacokinetics, and Effects of LGD-4033, a Novel Nonsteroidal Oral, Selective Androgen Receptor Modulator, in Healthy Young Men.” The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. Oxford University Press, Jan. 2013. Web. 22 Apr. 2017. Mohler, M. L., C. E. Bohl, A. Jones, C. C. Coss, R. Narayanan, Y. He, D. J. Hwang, J. T. Dalton, and D. D. Miller. “Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit.” Journal of medicinal chemistry. U.S. National Library of Medicine, 25 June 2009. Web. 22 Apr. 2017. Coss, Christopher C., Amanda Jones, Michael L. Hancock, Mitchell S. Steiner, and James T. Dalton. “Selective androgen receptor modulators for the treatment of late onset male hypogonadism.” Asian Journal of Andrology. Medknow Publications & Media Pvt Ltd, 2014. Web. 22 Apr. 2017. Dalton, J. T., R. P. Taylor, M. L. Mohler, and M. S. Steiner. “Selective androgen receptor modulators for the prevention and treatment of muscle wasting associated with cancer.” Current opinion in supportive and palliative care. U.S. National Library of Medicine, Dec. 2013. Web. 22 Apr. 2017. Narayanan, Ramesh, Sunjoo Ahn, Misty D. Cheney, Muralimohan Yepuru, Duane D. Miller, Mitchell S. Steiner, and James T. Dalton. “Selective Androgen Receptor Modulators (SARMs) Negatively Regulate Triple-Negative Breast Cancer Growth and Epithelial:Mesenchymal Stem Cell Signaling.” PLoS ONE. Public Library of Science, 2014. Web. 22 Apr. 2017. Jayaraman, Anusha et al. “Selective Androgen Receptor Modulator RAD140 Is Neuroprotective in Cultured Neurons and Kainate-Lesioned Male Rats.” Endocrinology 155.4 (2014): 1398–1406. PMC. Web. 23 Apr. 2017.